Service code s4102

Nutritional Cognitive Neuroscience is an interdisciplinary field that explores how nutrition affects cognition and brain health throughout lifespan. This field supports a personalized approach to nutritional interventions, which considers individual differences in nutritional status and brain health.

Neuromodulation aims to optimise, normalise, enchance, and maintain brain health and mental well-being by influencing the brain’s electrical, chemical, and physiological processes.

Scientific research has reached a consensus that the potential of nutraceuticals—compounds such as small molecules, nutrients, vitamins, minerals, essential amino and fatty acids, and plant extracts—to improve brain and overall bodily functions (the whole organism) is greater than previously thought.

Researchers believe that while food contains the nutrients we need, various factors can destroy or diminish many vitamins and minerals. Vitamins, in particular, are easily degraded by light, air, heat, and water. Cooking often destroys the vitamin content of foods. 

Moreover, the domestication of animals and plants has altered the composition and balance of vitamins, minerals, and other nutrients critical to human health, often in ways that do not support optimal metabolic functioning. The mass production of food has simplified our diets, significantly reducing the levels of trace elements, minerals, and vitamins essential for robust health. Human evolution has not had sufficient time to adapt to this nutritional shift.

Additionally, food-derived bioactive elements or vitamins are not always found in pure form but may exist in complex combinations. A risk of food mixing is that certain components could interact with others—such as carbohydrates or fats—to produce toxic, allergenic, or even carcinogenic substances.

In light of these factors, an individually adjusted (personalized), evidence-based nutritional and supplementation strategy is necessary to promote and maintain cognitive optimization, brain health, and mental well-being. Therefore, nutrition and supplementation can be considered natural bioregulatory intervention. The effectiveness of this approach was confirmed in a retrospective study that was single-blinded and actively controlled.

Our strategy

• make supplement and nutritional recommendations based on trustworthy information backed by unbiased actual scientific research,
• focus mostly on studies that were performed with actual humans, and not only on those that were done on animals or in petri-dishes,
• take a holistic approach: placing each study into context with the related research,
• go beyond the catchy statements to fully understand the entire study and how it relates to the big health picture,
• find a balance between multiple studies and keeping the integrity of the scientific findings.

The key principles of our strategy for developing an individualized program of nutraceuticals:

1. Scientific Approach to Substance Selection
We do not rely on public sources or popular information when selecting substances for a specific case. Instead, we consult specialized scientific databases. The scientific literature often presents information with far more detail and complex than what is found in popular internet articles or simplified nutrition courses. Our approach differs significantly from traditional nutritionists, who primarily focus on food and plant mixtures to compensate the deficiencies. We base our program on individual active compounds, which are carefully combined into sets of non-conflicting elements and administered within appropriate time windows during the day and year, depending on the organism's metabolism and physiological processes. This approach offers more precision and control over each compound, making our program more fine-tuned. However, one downside is that such program typically involves many substances. We do not recommend specific brands, as the same compound may be sold under different names and prices. Instead, we suggest the compounds themselves, allowing customers to choose the most cost-effective options. It is the customer's responsibility to source the compounds, as we do not supply them.

2. Interaction-Based Compound Combinations
We do not combine compounds mechanistically based on their known primary functions in the organism, as taught in typical nutrition courses. Instead, we examine how these substances interact with each other in each specific case. Sometimes, a compound is included not for its direct effect, but to enhance or protect another compound in the set. Various factors must be considered when creating these combinations (sets), which is why it's not possible to group all elements into one session, such as at breakfast, for example. Some compounds must be taken separately because they may not work well together or would be too numerous for one intake. Furthermore, the same compound taken at different times or in combination with other substances can produce different effects. This approach allows for the possibility of achieving different desired outcomes using the same compound under varying conditions.

Additionally, unlike nutritionists who often aim to compensate for dietary deficiencies, our primary focus is on optimizing specific physiological processes and enhancing self-regulation.

3. Pulsed Protocol for Substances
For certain compounds, we use a pulsed protocol, considering various factors. For example, some substances need to be taken separately, some may have cumulative effects that should be avoided, and some are tied to the chronobiology of specific organs or physiological processes. This means they must be administered at precise times when these organs or processes are most vulnerable and need support. Balancing all these factors is crucial when designing a program tailored to an individual’s needs.

4. Dosage Determination Based on Scientific Evidence
Dosages are based on published scientific or clinical studies relevant to a specific condition or symptom. Only effective dosages are considered. To maximize the desired effects of our program, the combination of compounds, timing, and dosages are all critical factors. These factors are personalized according to the individuals' health condition and are also informed by the results of their EEG analysis.

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Selected references

• Fingelkurts AA, Fingelkurts AA. (2023). Turning back the clock: A retrospective single-blind study on brain age change in response to nutraceuticals supplementation vs. lifestyle modifications. Brain Sci. 13(3):520.
• Gómez-Pinilla F. (2008). Brain foods: the effects of nutrients on brain function. Nat. Rev. Neurosci. 9(7):568-578.
• Buchman TG. (2002). The community of the self. Nature 420:246–251.
• Goldman AW, Burmeister Y, Cesnulevicius K, et al. (2015). Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient's autoregulatory capacity? Front. Physiol. 6:225.
• Grodner M, Anderson SL, DeYoung S. (2000). Vegetable victories. In: Foundations and Clinical Applications of Nutrition: A Nursing Approach. St. Louis, Mo: Mosby; 190.
• Kitano H. (2004). Biological robustness. Nat. Rev. Genet. 5:826–837.
• Kitano H, Oda K, Kimura T, et al. (2004). Metabolic syndrome and robustness tradeoffs. Diabetes 53(Suppl. 3):S6–S15.
• McKay DL, Perrone G, Rasmussen H, et al. (2000). Multivitamin/mineral supplementation improves plasma B-vitamin status and homocysteine concentration in healthy older adults consuming a folate-fortified diet. J Nutr. 130:3090-3096.
• McKay DL, Perrone G, Rasmussen H, et al. (2000). The effects of a multivitamin/mineral supplement on micronutrient status, antioxidant capacity and cytokine production in healthy older adults consuming a fortified diet. J Am Coll Nutr. 19:613-621.
• Zamroziewicz MK, Barbey AK. (2016). Nutritional cognitive neuroscience: Innovations for healthy brain aging. Front. Neurosci. 10:240.
• Droujinine I, Perrimon N. (2013). Defining the interorgan communication network: systemic coordination of organismal cellular processes under homeostasis and localized stress. Front. Cell. Infect. Microbiol. 3:82.